Written by Jillian Kubala, MS, RD on April 6, 2020 — Medically reviewed by Adrienne Seitz, MS, RD, LDN
Aging, which can be defined as the “time-related deterioration of the physiological functions necessary for survival and fertility,” is a process that most people would like to slow (1Trusted Source).
Some of its main causes include accumulated cellular damage caused by reactive molecules known as free radicals and the shortening of telomere, which are the structures located at the ends of chromosomes that play an important role in cellular division (1Trusted Source).
While aging is inevitable, increasing the human lifespan and slowing the aging process has been a focus of scientific research for decades.
Through that research, scientists have identified a large number of substances that have anti-aging properties, many of which can be taken as supplements by those looking for natural ways to decelerate the aging process and prevent age-related disease.
Note that this list is not exhaustive, and many other supplements may also offer anti-aging effects.
Here are 12 supplements with anti-aging properties.
Curcumin — the main active compound in turmeric — has been shown to possess powerful anti-aging properties, which are attributed to its potent antioxidant potential.
Cellular senescence occurs when cells stop dividing. As you age, senescent cells accumulate, which is believed to accelerate aging and disease progression (2Trusted Source, 3Trusted Source).
Research demonstrates that curcumin activates certain proteins, including sirtuins and AMP-activated protein kinase (AMPK), which helps delay cellular senescence and promotes longevity (4Trusted Source, 5Trusted Source).
Plus, curcumin has been shown to combat cellular damage and significantly increase the lifespan of fruit flies, roundworms, and mice. This compound has been shown to postpone age-related disease and alleviate age-related symptoms as well (6Trusted Source, 7Trusted Source).
This may be why turmeric intake has been associated with a reduced risk of age-related mental decline in humans (8Trusted Source).
You can increase your curcumin intake by using turmeric in recipes or taking curcumin supplements.
Curcumin is the main active compound in turmeric. It may slow aging by activating certain proteins and protecting against cellular damage.
Epigallocatechin gallate (EGCG) is a well-known polyphenol compound concentrated in green tea. It offers impressive health benefits, with research supporting its use to reduce the risk of certain cancers, as well as other health conditions like heart disease (9Trusted Source, 10Trusted Source, 11Trusted Source).
Among EGCG’s diverse array of potential health-promoting properties is its ability to promote longevity and protect against age-related disease development.
EGCG may slow aging by restoring mitochondrial function in cells and acting on pathways involved in aging, including the AMP-activated protein kinase signaling pathway (AMPK).
It also induces autophagy, the process by which your body removes damaged cellular material (12Trusted Source).
Green tea intake has been associated with a reduced risk of all-cause mortality, diabetes, stroke, and heart-disease-related death. Plus, animal studies have shown that it can protect against skin aging and wrinkles caused by ultraviolet (UV) light (13Trusted Source, 14Trusted Source, 15Trusted Source).
EGCG can be consumed by drinking green tea or taking concentrated supplements.
EGCG is a polyphenol compound concentrated in green tea that may improve mitochondrial function and promote autophagy. Green tea intake has been linked to a reduced risk of all-cause mortality.
Collagen is promoted as a fountain of youth for its potential to reduce the appearance of skin aging.
It’s an integral component of your skin that helps maintain skin structure. As you age, collagen production slows, leading to collagen loss in the skin that accelerates signs of aging like wrinkles.
Some research suggests that supplementing with collagen may reduce signs of aging, including wrinkles and dry skin.
For example, a 2019 study in 72 women demonstrated that taking a supplement that contained 2.5 grams of collagen — along with several other ingredients, including biotin — per day for 12 weeks significantly improved skin hydration, roughness, and elasticity (16Trusted Source).
Another study in 114 women found that treatment with 2.5 grams of collagen peptides for 8 weeks significantly reduced eye wrinkles and increased collagen levels in the skin (17Trusted Source).
Though these results are promising, keep in mind that many collagen studies are funded by companies that manufacture collagen products, which may influence study results.
Many types of collagen supplements are on the market, including powders and capsules.
Collagen is a popular dietary supplement that may help prevent skin aging by boosting collagen levels in your skin.
Coenzyme Q10 (CoQ10) is an antioxidant that your body produces. It plays essential roles in energy production and protects against cellular damage (18Trusted Source).
Research suggests that levels of CoQ10 decline as you age, and supplementing with it has been shown to improve certain aspects of health in older individuals.
For example, a study in 443 older adults demonstrated that supplementing with CoQ10 and selenium over 4 years improved their overall quality of life, reduced hospital visits, and slowed the deterioration of physical and mental performance (19Trusted Source).
CoQ10 supplements help reduce oxidative stress, a condition characterized by an accumulation of free radicals and other reactive molecules that accelerates the aging process and onset of age-related disease (20Trusted Source, 21Trusted Source).
Though CoQ10 shows promise as an anti-aging supplement, more evidence is needed before it can be recommended as a natural way to delay aging.
Be sure to consult a trusted healthcare professional before giving it a try.
CoQ10 is an important antioxidant that your body naturally produces. Some research shows that supplementing with it may slow age-related physical decline and improve quality of life in older adults.
5. Nicotinamide riboside and nicotinamide mononucleotide
Nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are precursors to nicotinamide adenine dinucleotide (NAD+).
NAD+ is a compound found in every cell in your body and involved in many critical processes, including energy metabolism, DNA repair, and gene expression (22, 23Trusted Source).
NAD+ levels decline with age, and this decline is thought to be associated with accelerated physical decline and the onset of age-related diseases like Alzheimer’s (23Trusted Source).
Animal studies have shown that supplementing with NAD+ precursors NMN and NR restores NAD+ levels and prevents age-related physical decline.
For example, a study in aging mice demonstrated that supplementing orally with NMN prevented age-associated genetic changes and improved energy metabolism, physical activity, and insulin sensitivity (24Trusted Source).
Additionally, a 2019 study in 12 men with an average age of 75 showed that supplementing with 1 gram of NR daily for 21 days increased NAD+ levels in skeletal muscle and reduced levels of inflammatory proteins in the body (25Trusted Source).
However, one of the authors in the study above owns stock in and serves as an advisor to the company that manufactured the NR supplement being studied, which may have skewed results (25Trusted Source).
A number of other animal studies have shown positive results related to supplementing with both NR and NMN. However, more human research is needed before strong conclusions on the anti-aging effects of NR and NMN can be made (26Trusted Source, 27Trusted Source).
Supplementing with NMR and NR may help boost NAD+ levels in your body and prevent age-associated genetic changes.
Crocin is a yellow carotenoid pigment in saffron, a popular, pricey spice that’s commonly used in Indian and Spanish cuisine.
Human and animal studies have shown that crocin offers many health benefits, including anticancer, anti-inflammatory, anti-anxiety, and antidiabetic effects (28Trusted Source).
Aside from the properties listed above, crocin has been researched for its potential to act as an anti-aging compound and protect against age-related mental decline (29Trusted Source).
Test-tube and rodent studies have demonstrated that crocin helps prevent age-related nerve damage by inhibiting the production of advanced glycation end products (AGEs) and reactive oxygen species (ROS), which are compounds that contribute to the aging process (30Trusted Source, 31Trusted Source).
Crocin has also been shown to help prevent aging in human skin cells by reducing inflammation and protecting against UV-light-induced cellular damage (32Trusted Source, 33Trusted Source).
Given that saffron is the most expensive spice in the world, a more cost-effective way to boost your crocin intake is by taking a concentrated saffron supplement.
Crocin, which is a pigment found in the spice saffron, shows promise as an anti-aging supplement. It may prevent cellular damage and reduce inflammation, which may promote longevity and prevent mental decline.
7–12. Other anti-aging supplements
Aside from those listed above, the following supplements have impressive anti-aging potential:
- Theanine. L-theanine is an amino acid concentrated in certain teas, including green tea. It may help protect against mental decline and has been shown to extend the lifespan of roundworms by around 5% (35Trusted Source, 36Trusted Source).
- Rhodiola. This medicinal plant has potent anti-inflammatory and anti-aging properties. One study in fruit flies demonstrated that treatment with Rhodiola rosea powder led to a 17% increase in their lifespan, on average (37Trusted Source, 38Trusted Source).
- Garlic. Garlic has powerful anti-inflammatory and antioxidant properties. Test-tube and rodent studies have shown that supplementing with this bulb may prevent UV-light-induced skin aging and wrinkles (39Trusted Source).
- Astragalus. Astragalus membranaceus is a stress-reducing herb used in traditional Chinese medicine. It may help combat aging by reducing oxidative stress, promoting immune function, and preventing cellular damage (40Trusted Source).
- Fisetin. Fisetin is a flavonoid compound that’s considered a senotherapeutic, meaning it can kill senescent cells. Rodent studies suggest that it may reduce the number of senescent cells in tissues and extend lifespan (41Trusted Source).
- Resveratrol. Resveratrol is a polyphenol in grapes, berries, peanuts, and red wine that may promote longevity by activating certain genes called sirtuins. It has been shown to increase the lifespan of fruit flies, yeasts, and nematodes (42Trusted Source).
Though these results are promising, more research in humans is needed to fully understand how these supplements may be used to promote longevity.
Research has shown that L-theanine, Rhodiola rosea, garlic, Astragalus membranaceus, fisetin, and resveratrol are supplements that may have anti-aging properties.
Certain supplements may help slow the aging process and promote a long, healthy life.
Curcumin, collagen, CoQ10, crocin, nicotinamide mononucleotide, and fesitin are just some of the substances that have been shown to offer anti-aging effects in research studies.
Nevertheless, while some studies suggest that taking certain supplements may help slow aging, the best way to promote longevity and overall health is to engage in healthy practices like consuming a nutritious diet, engaging in regular exercise, and reducing stress.