Release The Brakes On Muscle Growth

Creatine is a popular supplement that is commonly used to improve athletic performance and increase muscle mass. However, it may also have an effect on myostatin, a protein that plays a role in regulating muscle growth.

Myostatin is produced by muscle cells and released into the bloodstream. It acts as a “brake” on muscle growth, preventing the muscles from getting too big. When myostatin levels are high, muscle growth is limited. When myostatin levels are low, muscle growth is enhanced.

Normal mouse on the left, and the mouse on the right has myostatin inhibited.
A Normal Mouse on the left, and the mouse on the right is myostatin inhibited

There is some evidence to suggest that creatine can inhibit myostatin and increase muscle growth. For example, a study published in the Journal of the International Society of Sports Nutrition found that creatine supplementation increased muscle mass and reduced myostatin levels in mice. Another study published in the American Journal of Physiology-Endocrinology and Metabolism found similar results in humans.

It’s important to note that the evidence for this effect of creatine is still preliminary, and more research is needed to fully understand how it works. Additionally, it’s not clear whether this effect is seen in all individuals or only in certain populations.

Despite the potential for creatine to inhibit myostatin and increase muscle mass, it’s important to keep in mind that it’s just one piece of the puzzle when it comes to building muscle. A well-rounded training program and proper nutrition are also essential for optimal muscle growth.

In conclusion, creatine may have the potential to inhibit myostatin and enhance muscle growth, but more research is needed to fully understand this effect. As with any supplement, it’s important to consult with a healthcare provider before adding it to your routine

Effects of oral creatine and resistance training on myostatin and GASP-1

About the author: Brian Kitching
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